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low in lung, ovary, brain) and couples with Gq/11 and Gi/o (but not G12/13) to initiate MAPK and PLC cascades, with abnormal expression noted in some tumors (45)

Glutathione deficiency may promote cancer initiation (by failing to protect DNA from oxidative damage), while elevated glutathione in established tumors may promote cancer progression and treatment resistance (by protecting cancer cells from chemotherapy and radiation) [2][5]

Most experts recommend limiting use to twelve weeks followed by an equal rest period