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It acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in multiple tissues including adipose tissue and the liver that plays a role in cellular energy metabolism and fat storage

In particular, B12 injections may not be right for you if you have kidney disease, Lebers disease, or allergies to cyanocobalamin, cobalt, or other medications, foods, dyes, or preservatives

In the UK, B12 replacement is typically administered via intramuscular hydroxocobalamin injections for patients with confirmed deficiency, particularly those with malabsorption or pernicious anaemia, as specified in the BNF and NICE CKS guidance on B12 and folate deficiency anaemia

How Does a B12 Shot Work