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10.1248/bpb.b23-00477 94 MannaK.KhanZ

While a healthy, intact BBB tightly restricts the movement of these substances into the CNS compartment, these, and other myeloid-responsive factors, such as cytokines, are not fully restricted from entering the CNS, which may compromise BBB integrity through stimulation of perivascular Ms and microglia

Although most data derive from rodent studies, their consistent engagement of Keap1/Nrf2, SIRT1/FOXO3, VEGF/FAK, and mitochondrial regulatory cascades highlights tangible molecular entry points for future translational work

CS challenge stimulated the reduction of T-AOC and GSH in lung tissue, while high dosage of GHK-Cu pretreatment relieved the decrease of these expression levels in lung tissue