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Lymphocytes activate ECs and affect BBB permeability through cytokines like IL-6, IL-17, IL-22, and IFN- [266]

In related studies, NETs secreted by inflammation-activated neutrophils impaired tumor clearance by encircling cancer cells and blocking immune cells from exerting their normal anticancer effects (182, 183)

Telomere shortening is one of the hallmarks of aging, and telomerase activation has been linked to cellular rejuvenation and extended lifespan in research models

Therefore, we select several methods to compare with the Deep Learning method, which proposed in this paper in order to evaluate the performance of our method