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Interestingly, although not fully elaborated on, the authors also demonstrated binding sites for HIF1, STAT3, and NF-B in Shha , suggesting that this kinase may additionally act on these factors to regulate redox balance during wound healing 130

The activation of the Nrf2 pathway, on the other hand, has been proposed as one of the most crucial defense mechanisms against oxidative stress, and trigonelline defends the organism from oxidative stress by acting as an inhibitor of nuclear factor erythroid 2related factor 2 (Nrf2

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